Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1 (LRIG1) Antibody
234€ (50 µg)
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935106861
info@markelab.com
name
Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1 (LRIG1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx376393
tested applications
ELISA, WB, IHC, IF/ICC
Description
Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1 (LRIG1) Antibody is a Rabbit Polyclonal antibody against Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1 (LRIG1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1 (LRIG1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/5000 - 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96JA1 |
| Gene ID | 26018 |
| OMIM | 608868 |
| Alias | LIG1,LIG-1 |
| Background | Antibody anti-LRIG1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
LRIG1 is a transmembrane protein characterized by leucine-rich repeats (LRRs) and immunoglobulin-like (Ig-like) domains, which mediate protein-protein interactions. LRIG1 is expressed in various tissues and plays a critical role in regulating cell growth, differentiation, and signaling pathways, particularly in epidermal and neural cells. LRIG1 acts as a negative regulator of receptor tyrosine kinases (RTKs), such as EGFR (epidermal growth factor receptor), by promoting their degradation. LRIG1 maintains stem cell homeostasis in epithelial tissues, such as the skin and intestines. Dysregulation of LRIG1 expression is linked to cancer progression, where its loss contributes to unchecked cell proliferation and metastasis. Conversely, high LRIG1 levels correlate with better prognosis in certain cancers. LRIG1 also regulates neuronal signaling and plasticity, highlighting its broad functional importance in both development and disease.
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