Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1 (LRIG1) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1 (LRIG1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031198
tested applications
ELISA, WB
Description
LRIG1 act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein 1 (LRIG1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96JA1 |
| Gene ID | 26018 |
| OMIM | 608868 |
| Alias | LIG1,LIG-1 |
| Background | Antibody anti-LRIG1 |
| Status | RUO |
Descripción
LRIG1 is a transmembrane protein characterized by leucine-rich repeats (LRRs) and immunoglobulin-like (Ig-like) domains, which mediate protein-protein interactions. LRIG1 is expressed in various tissues and plays a critical role in regulating cell growth, differentiation, and signaling pathways, particularly in epidermal and neural cells. LRIG1 acts as a negative regulator of receptor tyrosine kinases (RTKs), such as EGFR (epidermal growth factor receptor), by promoting their degradation. LRIG1 maintains stem cell homeostasis in epithelial tissues, such as the skin and intestines. Dysregulation of LRIG1 expression is linked to cancer progression, where its loss contributes to unchecked cell proliferation and metastasis. Conversely, high LRIG1 levels correlate with better prognosis in certain cancers. LRIG1 also regulates neuronal signaling and plasticity, highlighting its broad functional importance in both development and disease.
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