LRIG1 antibody
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935106861
info@markelab.com
name
LRIG1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09953
tested applications
ELISA, WB
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 150 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96JA1 |
| Gene ID | 26018 |
| Alias | LIG1,LIG-1 |
| Background | Antibody anti-LRIG1 |
| Status | RUO |
| Note | Mol. Weight 150 kDa |
LRIG1 is a transmembrane protein characterized by leucine-rich repeats (LRRs) and immunoglobulin-like (Ig-like) domains, which mediate protein-protein interactions. LRIG1 is expressed in various tissues and plays a critical role in regulating cell growth, differentiation, and signaling pathways, particularly in epidermal and neural cells. LRIG1 acts as a negative regulator of receptor tyrosine kinases (RTKs), such as EGFR (epidermal growth factor receptor), by promoting their degradation. LRIG1 maintains stem cell homeostasis in epithelial tissues, such as the skin and intestines. Dysregulation of LRIG1 expression is linked to cancer progression, where its loss contributes to unchecked cell proliferation and metastasis. Conversely, high LRIG1 levels correlate with better prognosis in certain cancers. LRIG1 also regulates neuronal signaling and plasticity, highlighting its broad functional importance in both development and disease.
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