Leucine-Rich Repeat, Immunoglobulin-Like Domain And Transmembrane Domain-Containing Protein 1 (LRIT1) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Leucine-Rich Repeat, Immunoglobulin-Like Domain And Transmembrane Domain-Containing Protein 1 (LRIT1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026248
tested applications
ELISA, WB, FCM
Description
Possible role in phototransduction.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine-Rich Repeat, Immunoglobulin-Like Domain And Transmembrane Domain-Containing Protein 1 (LRIT1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9P2V4 |
| Alias | PAL,LRRC21,FIGLER9,Retina-specific protein,Leucine-rich repeat-containing protein 21,Photoreceptor-associated LRR superfamily protein,Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 |
| Background | Antibody anti-LRIT1 |
| Status | RUO |
Descripción
LRIT1 is a transmembrane protein that is part of the leucine-rich repeat (LRR) superfamily, characterized by its involvement in protein-protein interactions, particularly within neuronal and sensory systems. The structure of LRIT1 includes leucine-rich repeat regions and immunoglobulin (Ig)-like domains, which contribute to its roles in signal transduction and cellular adhesion. It is predominantly expressed in retinal photoreceptor cells and is crucial for synaptic organization and retinal signal processing. LRIT1 mutations have been linked to congenital stationary night blindness (CSNB), highlighting its importance in visual neurotransmission and synaptic connectivity. Its localization and function suggest that LRIT1 is a key component of the ribbon synapses in the retina, mediating interactions between photoreceptors and bipolar cells.
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