Leucine-Rich Repeat-Containing Protein 67 (LRRC67) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 67 (LRRC67) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026825
tested applications
ELISA, WB
Description
LRRC67 Antibody is a Rabbit Polyclonal antibody against LRRC67.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine-Rich Repeat-Containing Protein 67 (LRRC67) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7Z4L9 |
| Alias | LRRC67,Protein phosphatase 1 regulatory subunit 42 |
| Background | Antibody anti-PPP1R42 |
| Status | RUO |
Descripción
PPP1R42 is a regulatory subunit of protein phosphatase 1 (PP1), which modulates the catalytic activity of PP1 by targeting it to specific substrates, cellular compartments, or signaling pathways. PPP1R42 is involved in processes such as centrosome function, spindle dynamics, and cell division through its interaction with microtubule-associated proteins and centrosomal components. It regulates PP1 activity to control mitotic progression, ensuring proper chromosome segregation and cell cycle regulation. PPP1R42 is predominantly expressed in tissues undergoing high rates of cell division, such as germ cells and embryonic tissues. Dysregulation of PPP1R42 leads to centrosomal defects, abnormal spindle formation, and impaired cell division, contributing to chromosomal instability and cancer progression. Functional studies indicate that PPP1R42 is essential for maintaining centrosome integrity and coordinating PP1 activity with mitotic processes to ensure accurate cell division and genomic stability.
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