Leucine-Rich Repeat-Containing Protein 67 (LRRC67) Antibody

Background

PPP1R42 is a regulatory subunit of protein phosphatase 1 (PP1), which modulates the catalytic activity of PP1 by targeting it to specific substrates, cellular compartments, or signaling pathways. PPP1R42 is involved in processes such as centrosome function, spindle dynamics, and cell division through its interaction with microtubule-associated proteins and centrosomal components. It regulates PP1 activity to control mitotic progression, ensuring proper chromosome segregation and cell cycle regulation. PPP1R42 is predominantly expressed in tissues undergoing high rates of cell division, such as germ cells and embryonic tissues. Dysregulation of PPP1R42 leads to centrosomal defects, abnormal spindle formation, and impaired cell division, contributing to chromosomal instability and cancer progression. Functional studies indicate that PPP1R42 is essential for maintaining centrosome integrity and coordinating PP1 activity with mitotic processes to ensure accurate cell division and genomic stability.