Leucine-Rich Repeat-Containing Protein 46 (LRRC46) Antibody

Background

LRRC46 is a protein associated with microtubule organization and ciliogenesis studies indicate it plays a critical role in the assembly and stability of motile cilia particularly in tissues such as the respiratory tract and reproductive system where ciliary function is essential for mucus clearance and gamete transport LRRC46 has been shown to interact with axonemal components of cilia contributing to the regulation of ciliary beat frequency and coordination mutations in LRRC46 have been associated with primary ciliary dyskinesia (PCD) a disorder characterized by impaired ciliary function and chronic respiratory infections its expression is also linked to processes involving cellular polarity and signaling through the ciliary apparatus further studies aim to elucidate its precise molecular functions and its potential as a therapeutic target in ciliopathies and other disorders related to defective cilia