Leucine Rich Repeat Containing G Protein-Coupled Receptor 6 (LGR6) Antibody
52€ (10 µg)
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935106861
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name
Leucine Rich Repeat Containing G Protein-Coupled Receptor 6 (LGR6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015337
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against LGR6 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine Rich Repeat Containing G Protein-Coupled Receptor 6 (LGR6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HBX8 |
| Alias | LGR6,VTS20631,leucine-rich repeat-containing G protein-coupled receptor 6,leucine-rich repeat containing G protein-coupled receptor 6 |
| Background | Antibody anti-LGR6 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
LGR6 is another member of the LGR receptor family that functions as a receptor for R-spondins, regulating Wnt signaling. Similar to LGR4 and LGR5, LGR6 is involved in the regulation of stem cell biology, particularly in the hair follicle and skin regeneration. LGR6 plays a role in promoting epithelial differentiation and influencing the development of various tissues during embryogenesis. It is involved in signaling pathways that maintain stem cell populations in tissues such as the skin and the gastrointestinal tract, contributing to tissue homeostasis and repair. LGR6’s expression in hair follicle stem cells suggests a role in hair growth and regeneration. Dysregulation of LGR6 has been linked to skin disorders, and its involvement in Wnt signaling makes it an important player in cancer biology. Targeting LGR6 with therapeutic agents could hold potential in treating diseases related to stem cell dysregulation, including certain types of cancer and skin regeneration disorders.
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