Leucine Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) Antibody (HRP)

Background

LGR4 is a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) family, which is activated by R-spondins, a group of proteins that regulate Wnt signaling. LGR4 plays a significant role in tissue development, differentiation, and homeostasis, particularly in the epithelial cells of various organs, including the gastrointestinal tract, kidney, and skin. It is involved in modulating Wnt/β-catenin signaling pathways, which are crucial for cell proliferation, stem cell maintenance, and differentiation. LGR4 is implicated in regulating processes such as embryogenesis, organogenesis, and tissue repair. Dysregulation of LGR4 signaling has been associated with conditions like cancer, particularly colorectal cancer, and disorders of tissue regeneration. LGR4 also plays a role in controlling blood pressure and fluid balance, with potential therapeutic applications in hypertension and renal diseases.