Leucine Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) Antibody
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Description
LGR4 Antibody is a Rabbit Polyclonal against LGR4.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BXB1 |
| Alias | LGR4,GPR48,leucine-rich repeat-containing G protein-coupled receptor 4,leucine-rich repeat containing G protein-coupled receptor 4,DPSL,BNMD17 |
| Background | Antibody anti-LGR4 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
LGR4 is a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) family, which is activated by R-spondins, a group of proteins that regulate Wnt signaling. LGR4 plays a significant role in tissue development, differentiation, and homeostasis, particularly in the epithelial cells of various organs, including the gastrointestinal tract, kidney, and skin. It is involved in modulating Wnt/β-catenin signaling pathways, which are crucial for cell proliferation, stem cell maintenance, and differentiation. LGR4 is implicated in regulating processes such as embryogenesis, organogenesis, and tissue repair. Dysregulation of LGR4 signaling has been associated with conditions like cancer, particularly colorectal cancer, and disorders of tissue regeneration. LGR4 also plays a role in controlling blood pressure and fluid balance, with potential therapeutic applications in hypertension and renal diseases.
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Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin(NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP(By similarity).
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