Latrophilin-1 (LPHN1) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Latrophilin-1 (LPHN1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015338
tested applications
ELISA, IF/ICC
Description
Rabbit polyclonal antibody against LPHN1 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Latrophilin-1 (LPHN1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/100 - 1/500, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94910 |
| Alias | ADGRL1,LPHN1,latrophilin 1lectomedin-2,CIRL1,calcium-independent alpha-latrotoxin 1,CL1,CIRL/latrophilin 1, CIRL1, CL1, DEDBANP, LEC2 |
| Background | Antibody anti-ADGRL1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ADGRL1, also known as Latrophilin-1, is a member of the adhesion GPCR family prominently expressed in neuronal and endothelial tissues. It plays a vital role in synapse formation, organization, and maintenance by mediating trans-synaptic adhesion through interactions with partners such as teneurins. These interactions are crucial for establishing proper neural wiring and connectivity, particularly in the central nervous system. In addition to its neural roles, ADGRL1 contributes to endothelial cell adhesion and communication, promoting vascular stability and angiogenesis. Its ability to interact with multiple extracellular matrix proteins underscores its role in maintaining structural and functional integrity within tissues. Dysregulation of ADGRL1 has been implicated in a variety of neurodevelopmental disorders, including autism spectrum disorders and epilepsy, as well as in vascular dysfunctions and cancer progression, highlighting its importance in both neural and systemic physiology.
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