Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) Antibody
637€ (100 µl)
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Name
Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx113369
Tested Applications
ELISA, WB, IF/ICC
Description
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 Antibody is a Rabbit Polyclonal antibody against Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) Immunogen: Human KIR2DS4. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43632 |
| Gene ID | 3809 |
| OMIM | 604955 |
| Alias | CD158 antigen-like family member I,KKA3,KIR1D,Natural killer-associated transcript 8,NKAT8,CD158I,KIR412,NKAT-8,KIR-2DS4,P58 natural killer cell receptor clones CL-39/CL-17 |
| Background | Antibody anti-KIR2DS4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) is part of the Killer-cell Immunoglobulin-like Receptor (KIR) family, which plays a central role in the immune system, specifically in regulating natural killer (NK) cells and certain T-cell functions. KIR2DS4 is one of the activating receptors in the KIR family and is particularly involved in identifying cells that may be infected, stressed, or tumorigenic. KIR receptors, including KIR2DS4, contribute to the immune system's adaptability through interactions with human leukocyte antigen (HLA) molecules, typically class I. However, unlike many KIR receptors that mediate inhibitory signals, KIR2DS4 is an activating receptor. It provides stimulatory signals that help NK cells become cytotoxic toward specific target cells. KIR genes, including KIR2DS4, are highly polymorphic, with substantial genetic variation between individuals, contributing to variations in immune response. KIR genes are clustered on chromosome 19, and their expression varies across different populations, impacting immune response diversity. This variation has implications for disease susceptibility, transplantation compatibility, and response to certain therapies.
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