Kallistatin (SERPINA4) Antibody
292.5€ (80 µl)
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935106861
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name
Kallistatin (SERPINA4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx033408
tested applications
ELISA, WB, IHC, FCM
Description
SERPINA4 inhibits human amidolytic and kininogenase activities of tissue kallikrein. The inhibition is achieved by formation of an equimolar, heat and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Kallistatin (SERPINA4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29622 |
| Alias | KAL,KST,PI4,KLST,PI-4,kallistatin,Kallikrein inhibitor,Peptidase inhibitor 4,Serpin A4 |
| Background | Antibody anti-SERPINA4 |
| Status | RUO |
Descripción
SERPINA4, also known as kallistatin, is a member of the serine protease inhibitor (serpin) superfamily, which plays a critical role in the regulation of various proteolytic processes in the body. This gene is located on chromosome 14q32.13, a region that houses a cluster of other serpin genes, including SERPINA1 and SERPINA3. Kallistatin was first identified as a potent inhibitor of tissue kallikrein, a serine protease involved in the generation of kinins, which are peptides that contribute to blood pressure regulation, inflammation, and pain. Kallistatin is synthesized primarily in the liver and circulates in the blood, but it is also expressed in other tissues, including the heart, kidneys, and vasculature. The protein encoded by SERPINA4 is involved in a wide range of physiological processes, including the regulation of blood pressure, angiogenesis, inflammation, and oxidative stress
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