Interleukin 8 Receptor Alpha / IL8RA (CXCR1) Antibody

Este producto es parte de CXCR - C-X-C motif chemokine receptor
Product Graph
741€ (1 ml)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Interleukin 8 Receptor Alpha / IL8RA (CXCR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx173192
tested applications
WB, IHC, IF/ICC

Description

This product is currently in development. The lead time for this product may be several months. Please contact us at

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Interleukin 8 Receptor Alpha / IL8RA (CXCR1)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Purification
Purified by Protein A and Protein G affinity chromatography.
Size 1
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Please enquire.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
CXCR1,C-X-C motif chemokine receptor 1,high affinity interleukin-8 receptor A,CXCR1-like ,IL-8 receptor α,CD128,CD181,CKR-1,IL8R1,IL8RA,CMKAR1,IL8RBA,CDw128a,C-C-CKR-1
Background
Antibody anti-CXCR1
Status
RUO

Descripción

CXCR1 is a G protein-coupled receptor (GPCR) in the CXC chemokine receptor family, binding interleukin-8 (IL-8) with high affinity. It is primarily expressed on neutrophils, where it mediates chemotaxis, degranulation, and respiratory burst during inflammation. CXCR1 activation triggers pathways like PI3K, PLC-β, and MAPK, leading to calcium mobilization and actin cytoskeleton rearrangement for cell migration. It also activates integrins, enhancing neutrophil adhesion and migration. CXCR1 plays key roles in infections and inflammation but contributes to diseases like chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis due to excessive neutrophil recruitment. In cancer, CXCR1 is linked to cancer stem cell maintenance, survival, and chemoresistance, particularly in breast cancer, where IL-8 signaling promotes tumor progression and immune evasion. It also facilitates angiogenesis by recruiting endothelial and immune cells for neovascularization. CXCR1 signaling is more sustained compared to CXCR2, allowing prolonged neutrophil activation. Its dysregulation contributes to chronic inflammation and immune pathology, positioning it as a target for therapies aimed at reducing tissue damage and tumor growth.

Related Products

EH0705

Human CXCR1 (C-X-C chemokine receptor type 1) ELISA Kit

Ver Producto
FNab02099

CXCR1 antibody

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA(GRO) with a low affinity.

Ver Producto
QT-EH0705

Human CXCR1 (C-X-C chemokine receptor type 1) QuickTest ELISA Kit

Ver Producto