C-X-C Chemokine Receptor Type 1 (CXCR1) Antibody
357.5€ (100 µg)
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Name
C-X-C Chemokine Receptor Type 1 (CXCR1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037605
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the CXCR1 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: C-X-C Chemokine Receptor Type 1 (CXCR1) Immunogen: A peptide corresponding to N-terminal region of Human CXCR1 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 40 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25024 |
| Gene ID | 3577 |
| OMIM | 146929 |
| Alias | CXCR1,C-X-C motif chemokine receptor 1,high affinity interleukin-8 receptor A,CXCR1-like ,IL-8 receptor α,CD128,CD181,CKR-1,IL8R1,IL8RA,CMKAR1,IL8RBA,CDw128a,C-C-CKR-1 |
| Background | Antibody anti-CXCR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CXCR1 is a G protein-coupled receptor (GPCR) in the CXC chemokine receptor family, binding interleukin-8 (IL-8) with high affinity. It is primarily expressed on neutrophils, where it mediates chemotaxis, degranulation, and respiratory burst during inflammation. CXCR1 activation triggers pathways like PI3K, PLC-β, and MAPK, leading to calcium mobilization and actin cytoskeleton rearrangement for cell migration. It also activates integrins, enhancing neutrophil adhesion and migration. CXCR1 plays key roles in infections and inflammation but contributes to diseases like chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis due to excessive neutrophil recruitment. In cancer, CXCR1 is linked to cancer stem cell maintenance, survival, and chemoresistance, particularly in breast cancer, where IL-8 signaling promotes tumor progression and immune evasion. It also facilitates angiogenesis by recruiting endothelial and immune cells for neovascularization. CXCR1 signaling is more sustained compared to CXCR2, allowing prolonged neutrophil activation. Its dysregulation contributes to chronic inflammation and immune pathology, positioning it as a target for therapies aimed at reducing tissue damage and tumor growth.
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