Interleukin 8 Receptor Alpha / IL8RA (CXCR1) Antibody

Este producto es parte de CXCR - C-X-C motif chemokine receptor
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Interleukin 8 Receptor Alpha / IL8RA (CXCR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037605
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the CXCR1 protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Interleukin 8 Receptor Alpha / IL8RA (CXCR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_000625
Alias
CXCR1,C-X-C motif chemokine receptor 1,high affinity interleukin-8 receptor A,CXCR1-like ,IL-8 receptor α,CD128,CD181,CKR-1,IL8R1,IL8RA,CMKAR1,IL8RBA,CDw128a,C-C-CKR-1
Background
Antibody anti-CXCR1
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

CXCR1 is a G protein-coupled receptor (GPCR) in the CXC chemokine receptor family, binding interleukin-8 (IL-8) with high affinity. It is primarily expressed on neutrophils, where it mediates chemotaxis, degranulation, and respiratory burst during inflammation. CXCR1 activation triggers pathways like PI3K, PLC-β, and MAPK, leading to calcium mobilization and actin cytoskeleton rearrangement for cell migration. It also activates integrins, enhancing neutrophil adhesion and migration. CXCR1 plays key roles in infections and inflammation but contributes to diseases like chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis due to excessive neutrophil recruitment. In cancer, CXCR1 is linked to cancer stem cell maintenance, survival, and chemoresistance, particularly in breast cancer, where IL-8 signaling promotes tumor progression and immune evasion. It also facilitates angiogenesis by recruiting endothelial and immune cells for neovascularization. CXCR1 signaling is more sustained compared to CXCR2, allowing prolonged neutrophil activation. Its dysregulation contributes to chronic inflammation and immune pathology, positioning it as a target for therapies aimed at reducing tissue damage and tumor growth.

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