Human CXCR1(C-X-C chemokine receptor type 1) ELISA Kit

Este producto es parte de CXCR - C-X-C motif chemokine receptor
Human CXCR1(C-X-C chemokine receptor type 1) ELISA Kit

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935106861

info@markelab.com

Precio

Precio a consultar

Elisa Kits CXCR1

proveedor

FineTest

reference

EH0705

Tested Applications

reactivity

human

status

RUO

clonality


Background

CXCR1 is a G protein-coupled receptor (GPCR) in the CXC chemokine receptor family, binding interleukin-8 (IL-8) with high affinity. It is primarily expressed on neutrophils, where it mediates chemotaxis, degranulation, and respiratory burst during inflammation. CXCR1 activation triggers pathways like PI3K, PLC-β, and MAPK, leading to calcium mobilization and actin cytoskeleton rearrangement for cell migration. It also activates integrins, enhancing neutrophil adhesion and migration. CXCR1 plays key roles in infections and inflammation but contributes to diseases like chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis due to excessive neutrophil recruitment. In cancer, CXCR1 is linked to cancer stem cell maintenance, survival, and chemoresistance, particularly in breast cancer, where IL-8 signaling promotes tumor progression and immune evasion. It also facilitates angiogenesis by recruiting endothelial and immune cells for neovascularization. CXCR1 signaling is more sustained compared to CXCR2, allowing prolonged neutrophil activation. Its dysregulation contributes to chronic inflammation and immune pathology, positioning it as a target for therapies aimed at reducing tissue damage and tumor growth.

Características del producto

category

ELISA Kits


reactivity

human


test range

31.25-2000pg/ml


assay type

Sandwich ELISA, Double Antibody


assay data

Quantitative


detection method

Colorimetric


sample type

Serum,Plasma,Tissue homogenates,Other biological fluids


size 1

96T


alias

CXCR1,C-X-C motif chemokine receptor 1,high affinity interleukin-8 receptor A,CXCR1-like ,IL-8 receptor α,CD128,CD181,CKR-1,IL8R1,IL8RA,CMKAR1,IL8RBA,CDw128a,C-C-CKR-1


storage

2-8 °C for 6 months


or code

CXCR1


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