Interleukin 6 (IL6) Antibody
383.5€ (100 µl)
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name
Interleukin 6 (IL6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015895
tested applications
ELISA
Description
Interleukine 6 (IL-6) is a cytokine produced primarily by stimulated monocytes, fibroblasts and epithelial cells.It has a wide variety of biological functions through activating a cellsurface signaling assembly composed of IL6, IL6RA, and the shared signaling receptor gp130.The cytokine plays an essential role in the final differentiation of b-cells into Igsecreting cells, and induces myeloma, plasmacytoma growth, nerve cells differentiations.In addition, IL-6 is an important regulator of acute phase reaction.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 6 (IL6) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05231 |
| Gene ID | 3569 |
| OMIM | 147620 |
| Alias | IL-6,BSF,HGF,HSF,IFNB2,CDF,B-cell stimulatory factor 2 |
| Background | Antibody anti-IL6 |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
IL6 is a pleiotropic cytokine involved in regulating immune responses, inflammation, and hematopoiesis It is produced by macrophages, T cells, fibroblasts, and endothelial cells in response to infections, trauma, or tissue damage IL6 activates downstream signaling through its receptor, IL-6R, and the JAK/STAT3 pathway, driving acute-phase protein synthesis, such as CRP and fibrinogen, and promoting B cell differentiation into plasma cells Dysregulated IL6 expression is associated with chronic inflammation, autoimmune diseases like rheumatoid arthritis, and cancer progression, where it promotes tumor growth, survival, and angiogenesis IL6 also contributes to cytokine storm syndrome in conditions like COVID-19, where excessive IL6 leads to hyperinflammation and organ damage Targeting IL6 signaling with anti-IL6 therapies, such as tocilizumab, has shown efficacy in treating autoimmune diseases and cytokine-driven conditions
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