Interleukin-4 receptor subunit alpha (IL4R) Antibody

Este producto es parte de IL4R - interleukin 4 receptor
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169€ (20 µl)

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935106861
info@markelab.com
name
Interleukin-4 receptor subunit alpha (IL4R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx346914
tested applications
ELISA, WB

Description

Interleukin-4 receptor subunit alpha (IL4R) Antibody is a Rabbit Polyclonal antibody for the detection of Sus scrofa IL4R.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Interleukin-4 receptor subunit alpha (IL4R)
Host
Rabbit
Reactivity
Pig
Recommended Dilution
WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G chromatography.
Size 1
20 µl
Size 2
50 µl
Size 3
100 µl
Size 4
200 µl
Size 5
1 ml
Form
Liquid
Tested Applications
ELISA, WB
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q863Z5
Alias
Interleukin-4 receptor subunit alpha,CD124,IL4RA,IL-4RA,IL-4R subunit alpha,IL-4R-alpha
Background
Antibody anti-IL4R
Status
RUO

Descripción

The IL4R gene encodes the interleukin-4 receptor alpha (IL-4Rα) subunit, which plays a critical role in the immune system, especially in the regulation of T-helper cell responses. IL-4Rα serves as the receptor for two important cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), both of which influence various aspects of immune and inflammatory responses, including antibody production and the polarization of T-helper cells towards the Th2 phenotype. IL-4R signaling is essential in allergic responses, asthma, and other conditions associated with elevated IgE levels and eosinophilia. IL4Rα exists in both membrane-bound and soluble forms, with the soluble form inhibiting the actions of IL-4 by acting as a decoy receptor. IL4Rα is expressed across several cell types, including T and B lymphocytes, monocytes, macrophages, eosinophils, and endothelial cells. This widespread expression reflects the receptor’s importance in orchestrating responses to pathogens, allergens, and other environmental challenges. Given its central role in modulating immune responses, IL4R has become a target of therapeutic interest, particularly in conditions such as allergic asthma, atopic dermatitis, and certain autoimmune diseases.

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