Interleukin 4 (IL4) Antibody
292.5€ (80 µl)
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name
Interleukin 4 (IL4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032452
tested applications
ELISA, WB, IHC, FCM
Description
IL4 is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 4 (IL4) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05112 |
| Alias | BSF1,IL-4,BCGF1,BSF-1,BCGF-1,B-cell stimulatory factor 1,Binetrakin,Lymphocyte stimulatory factor 1,Pitrakinra |
| Background | Antibody anti-IL4 |
| Status | RUO |
Descripción
Interleukin-4 (IL4) is a crucial cytokine in the immune system, primarily involved in the regulation of humoral (antibody-mediated) immune responses and the differentiation of immune cells. It is produced by several immune cells, including activated CD4+ T cells (specifically Th2 cells), mast cells, basophils, eosinophils, and, to a lesser extent, CD8+ T cells. IL-4 is a member of the interleukin family of cytokines and plays a key role in driving the differentiation of naïve helper T cells (Th0) into Th2 cells, which are central to the adaptive immune response. This cytokine is also vital in inducing B cell class switching to immunoglobulin E (IgE), a process essential for allergic reactions. In addition to its immune-regulatory functions, IL-4 is heavily involved in allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis. IL-4 mediates a wide range of biological effects that contribute to inflammation, allergy, and immune system modulation.
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