Interleukin 24 (IL24) Antibody
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Pida mas información
935106861
info@markelab.com
Precio
312€ (60 µl)
Antibody anti-IL24
proveedor
Abbexareference
abx001544Tested Applications
WB, IHCreactivity
Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
IL24 Antibody is a Rabbit Polyclonal antibody against IL24. This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Background
Interleukin 24 (IL24) is a cytokine belonging to the IL-10 family, which includes other related cytokines such as IL-10, IL-19, IL-20, IL-22, and IL-26. IL-24 was first identified as melanoma differentiation-associated gene-7 (mda-7), due to its expression being upregulated during the process of melanoma cell differentiation. It plays a key role in immune regulation, cell survival, apoptosis, and the modulation of inflammatory responses. IL-24 is unique in its ability to induce apoptosis selectively in cancer cells without affecting normal cells, making it a promising therapeutic target for cancer treatment. IL-24 is produced by a variety of immune cells, including macrophages, monocytes, and T-cells, and is involved in both immune modulation and inflammation. Its expression can be triggered by pro-inflammatory signals, such as TNF-α and IFN-γ
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Mouse, Rat
immunogen target
Interleukin 24 (IL24)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC
purification
Purified by affinity chromatography.
recommended dilution
WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol.
size 1
60 µl
size 2
120 µl
size 3
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
IL24
dry ice
No
availability
Shipped within 5-10 working days.
alias
C49A,FISP,MDA7,MOB5,ST16,IL10B,Melanoma differentiation-associated gene 7 protein,Suppression of tumorigenicity 16 protein
uniprot id
NCBI accession
NP_001172085.1
note
Concentration: 1 mg/ml -
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