Interleukin 24 (IL24) Antibody

Este producto es parte de IL24 - interleukin 24
Interleukin 24 (IL24) Antibody

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935106861

info@markelab.com

Precio

312€ (60 µl)

Antibody anti-IL24

proveedor

Abbexa

reference

abx001544

Tested Applications

WB, IHC

reactivity

Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

IL24 Antibody is a Rabbit Polyclonal antibody against IL24. This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].


Background

Interleukin 24 (IL24) is a cytokine belonging to the IL-10 family, which includes other related cytokines such as IL-10, IL-19, IL-20, IL-22, and IL-26. IL-24 was first identified as melanoma differentiation-associated gene-7 (mda-7), due to its expression being upregulated during the process of melanoma cell differentiation. It plays a key role in immune regulation, cell survival, apoptosis, and the modulation of inflammatory responses. IL-24 is unique in its ability to induce apoptosis selectively in cancer cells without affecting normal cells, making it a promising therapeutic target for cancer treatment. IL-24 is produced by a variety of immune cells, including macrophages, monocytes, and T-cells, and is involved in both immune modulation and inflammation. Its expression can be triggered by pro-inflammatory signals, such as TNF-α and IFN-γ

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Mouse, Rat


immunogen target

Interleukin 24 (IL24)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC


purification

Purified by affinity chromatography.


recommended dilution

WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol.


size 1

60 µl


size 2

120 µl


size 3

200 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

IL24


dry ice

No


availability

Shipped within 5-10 working days.


alias

C49A,FISP,MDA7,MOB5,ST16,IL10B,Melanoma differentiation-associated gene 7 protein,Suppression of tumorigenicity 16 protein


NCBI accession

NP_001172085.1


note

Concentration: 1 mg/ml -


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