Interleukin 10 Receptor Beta (IL10RB) Antibody

Este producto es parte de IL10RB - Interleukin 10 Receptor Beta
Interleukin 10 Receptor Beta (IL10RB) Antibody

Pida mas información

935106861

info@markelab.com

Precio

637€ (100 µl)

Antibody anti-IL10RB

proveedor

Abbexa

reference

abx113233

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Interleukin 10 Receptor, Beta Antibody is a Rabbit Polyclonal antibody against Interleukin 10 Receptor, Beta.


Background

IL10RB is a shared receptor subunit within the IL10 receptor complex that interacts with IL10RA to propagate IL10 signaling It is widely expressed across immune and non-immune cell types, highlighting its role in diverse biological processes beyond IL10 signaling IL10RB forms a functional receptor complex with IL10RA and is also involved in the signaling pathways of cytokines such as IL22, IL26, and type III interferons (IFN-λ) Upon binding IL10, IL10RB recruits TYK2 kinase, facilitating activation of the JAK1/STAT3 signaling cascade to suppress pro-inflammatory cytokines and regulate immune tolerance Mutations in IL10RB lead to disrupted IL10 signaling and are strongly linked to severe early-onset IBD, systemic inflammation, and immune dysregulation IL10RB’s shared use in other cytokine pathways highlights its broad immunoregulatory function, making it crucial in the resolution of inflammation and antiviral immune responses Dysregulation of IL10RB has been associated with chronic inflammatory disorders, autoimmunity, and heightened susceptibility to viral infections Therapeutic approaches aimed at modulating IL10RB activity are being explored for managing inflammatory and infectious diseases, as enhancing IL10RB signaling can reestablish immune balance and prevent tissue damage caused by excessive inflammation

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Interleukin 10 Receptor Beta (IL10RB)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB


purification

Antigen Affinity Chromatography.


recommended dilution

Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol.


size 1

100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

IL10RB


dry ice

No


availability

Shipped within 5-10 working days.


alias

CRFB4,Cytokine receptor family 2 member 4,CRF2-4,Interleukin-10 receptor subunit 2,IL-10R subunit 2,IL-10R2


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