Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015194
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against IL1RAPL2 protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human IL1RAPL2. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NP60 |
| Alias | IL1RAPL2,IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1 |
| Background | Antibody anti-IL1RAPL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL1RAPL2 is a structurally related protein in the IL-1 receptor family that exhibits specialized functions in neuronal signaling, synaptic development, and immune regulation. It shares similarities with IL1RAP but has distinct patterns of expression, being predominantly found in developing neurons and immune cells. IL1RAPL2 interacts with downstream effectors to regulate cytokine signaling, dendritic spine formation, and synaptic plasticity, influencing neurodevelopment and immune modulation. In neurons, IL1RAPL2 promotes excitatory synapse formation and dendrite maturation, which are critical for cognitive function, neuronal communication, and brain connectivity. Dysregulation or mutations in IL1RAPL2 have been associated with neurodevelopmental disorders, including autism spectrum disorders and intellectual disabilities, where altered neuronal connectivity and synaptic function contribute to cognitive impairment and behavioral deficits. Knockdown models exhibit reduced synaptic development, defective dendritic growth, and impaired immune signaling, highlighting its importance in balancing neurodevelopment, synaptic organization, and immune responses.
Productos relacionados
Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Antibody
Rabbit polyclonal antibody against IL1RAPL2 protein. Immunogen region is Internal.…
Ver producto
Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Antibody
The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interl…
Ver producto
Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Antibody
Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) is a member of the interleukin 1 receptor family. Thi…
Ver producto