Interleukin 1 Receptor Accessory Protein Like 1 (IL1RAPL1) Antibody
383.5€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Interleukin 1 Receptor Accessory Protein Like 1 (IL1RAPL1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx224394
Tested Applications
ELISA, WB, IF/ICC, FCM
Description
IL1RAPL1 Antibody is a Mouse Monoclonal against IL1RAPL1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 1 Receptor Accessory Protein Like 1 (IL1RAPL1) Immunogen: Purified recombinant fragment of human IL1RAPL1 (AA: 541-694) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 80 kDa |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NZN1 |
| Gene ID | 11141 |
| OMIM | 300143 |
| Alias | IL1RAPL1,IL1R8, IL1RAPL, IL-1RAPL-1, IL-1-RAPL-1, IL1RAPL-1,OPHN4 |
| Background | Antibody anti-IL1RAPL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL1RAPL1, a neuronal protein in the IL-1 receptor family, regulates synapse formation, neuronal maturation, and cognitive processes critical for brain development and function. It interacts with postsynaptic density proteins, including PSD-95 and Rho GTPases, to modulate dendritic spine formation, excitatory synaptic activity, and synaptic plasticity, processes vital for learning and memory. IL1RAPL1 is primarily expressed in the brain, particularly in the cortex, hippocampus, and cerebellum, where it facilitates proper neural connectivity and neurotransmission. Mutations, deletions, or loss of IL1RAPL1 function are strongly linked to X-linked intellectual disability, autism spectrum disorders, and epilepsy, as disrupted synaptic organization leads to impaired cognitive function and abnormal behavior. Functional studies reveal defects in synaptic organization, dendritic arborization, and reduced synaptic plasticity in IL1RAPL1-deficient models. Knockout studies highlight impaired learning, memory deficits, and altered excitatory signaling, emphasizing its essential role in neuronal development, synapse regulation, and neurodevelopmental health.
Productos relacionados
Interleukin 1 Receptor Accessory Protein Like 1 (IL1RAPL1) Antibody
IL1RAPL1 Antibody is a Rabbit Polyclonal antibody against IL1RAPL1. The protein encoded by this gene is a member of the …
Ver producto Interleukin 1 Receptor Accessory Protein Like 1 (IL1RAPL1) Antibody
Interleukin 1 Receptor Accessory Protein-Like 1 Antibody is a Rabbit Polyclonal antibody against Interleukin 1 Receptor …
Ver producto
Interleukin 1 Receptor Accessory Protein Like Protein 1 (IL1RAPL1) Antibody
Interleukin 1 Receptor Accessory Protein Like Protein 1 Antibody is a Rabbit Polyclonal against Interleukin 1 Receptor A…
Ver producto