IL1RAPL1 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
IL1RAPL1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab04245
Tested Applications
ELISA, WB, IHC, IF, IP
Description
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | interleukin 1 receptor accessory protein-like 1 (IL1RAPL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 66-75 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NZN1 |
| Gene ID | 11141 |
| Alias | IL1RAPL1,IL1R8, IL1RAPL, IL-1RAPL-1, IL-1-RAPL-1, IL1RAPL-1,OPHN4 |
| Background | Antibody anti-IL1RAPL1 |
| Status | RUO |
| Note | Mol. Weight 66-75 kDa |
Background
IL1RAPL1, a neuronal protein in the IL-1 receptor family, regulates synapse formation, neuronal maturation, and cognitive processes critical for brain development and function. It interacts with postsynaptic density proteins, including PSD-95 and Rho GTPases, to modulate dendritic spine formation, excitatory synaptic activity, and synaptic plasticity, processes vital for learning and memory. IL1RAPL1 is primarily expressed in the brain, particularly in the cortex, hippocampus, and cerebellum, where it facilitates proper neural connectivity and neurotransmission. Mutations, deletions, or loss of IL1RAPL1 function are strongly linked to X-linked intellectual disability, autism spectrum disorders, and epilepsy, as disrupted synaptic organization leads to impaired cognitive function and abnormal behavior. Functional studies reveal defects in synaptic organization, dendritic arborization, and reduced synaptic plasticity in IL1RAPL1-deficient models. Knockout studies highlight impaired learning, memory deficits, and altered excitatory signaling, emphasizing its essential role in neuronal development, synapse regulation, and neurodevelopmental health.
Productos relacionados
Interleukin 1 Receptor Accessory Protein Like 1 (IL1RAPL1) Antibody
IL1RAPL1 Antibody is a Rabbit Polyclonal antibody against IL1RAPL1. The protein encoded by this gene is a member of the …
Ver producto
Interleukin 1 Receptor Accessory Protein Like 1 (IL1RAPL1) Antibody
Interleukin 1 Receptor Accessory Protein-Like 1 Antibody is a Rabbit Polyclonal antibody against Interleukin 1 Receptor …
Ver producto
Interleukin 1 Receptor Accessory Protein Like Protein 1 (IL1RAPL1) Antibody
Interleukin 1 Receptor Accessory Protein Like Protein 1 Antibody is a Rabbit Polyclonal against Interleukin 1 Receptor A…
Ver producto