Interleukin 1 Receptor Accessory Protein (IL1RAP) Antibody
169€ (20 µl)
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Name
Interleukin 1 Receptor Accessory Protein (IL1RAP) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx320349
Tested Applications
ELISA, IHC
Description
IL1RAP Antibody is a Rabbit Polyclonal against IL1RAP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 1 Receptor Accessory Protein (IL1RAP) Immunogen: Recombinant human Interleukin-1 receptor accessory protein (21-356AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NPH3 |
| Gene ID | 3556 |
| NCBI Accession | NP_001161400.1, NM_001167928.1 |
| OMIM | 602626 |
| Alias | C3orf13, IL-1R-3, IL-1R3, IL-1RAcP,IL1RAP,Interleukin-1 receptor 3,IL-1 receptor accessory protein,IL-1RAcP |
| Background | Antibody anti-IL1RAP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL1RAP is a coreceptor that amplifies the interleukin-1 (IL-1) signaling cascade, which mediates inflammatory, immune, and stress responses. It forms a complex with the interleukin-1 receptor (IL-1R) and IL-1 ligand, facilitating the recruitment of the adaptor protein MyD88 and downstream activation of NF-κB, MAPK, and JNK pathways. These pathways lead to the transcription of pro-inflammatory cytokines, chemokines, and immune mediators critical for host defense. IL1RAP is widely expressed in immune cells such as monocytes, macrophages, dendritic cells, and T cells, playing pivotal roles in acute and chronic inflammatory responses, immune surveillance, and tissue repair. Beyond immunity, IL1RAP is overexpressed in cancers such as acute myeloid leukemia (AML) and solid tumors, where it enhances tumor proliferation and survival by supporting inflammatory microenvironments. Its role as a therapeutic target in inflammation and oncology is under investigation. Knockdown studies demonstrate impaired IL-1 signaling, reduced cytokine production, and weakened immune activation, underscoring its role as a crucial signaling scaffold in inflammation, immunity, and disease pathology.
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