Interleukin 1 Beta (IL1B) Antibody
383.5€ (100 µl)
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935106861
info@markelab.com
name
Interleukin 1 Beta (IL1B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx011665
tested applications
ELISA, IHC, IF/ICC
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 1 Beta (IL1B) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01584 |
| Gene ID | 3553 |
| OMIM | 147720 |
| Alias | IL-1F2, IL-1β, IL1β,IL-1 beta,IL1 beta,IL-1b,IL1b,IL1B |
| Background | Antibody anti-IL1B |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
IL1B is a major pro-inflammatory cytokine that belongs to the IL-1 family and plays a central role in inflammation, fever induction, and host defense. It is synthesized as an inactive precursor (pro-IL1B) in response to pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) and is cleaved into its active form by caspase-1 through inflammasome activation. IL1B binds to its receptor IL1R1, forming a signaling complex with IL1RAP, which activates downstream NF-κB, MAPK, and JNK pathways to drive the expression of cytokines, chemokines, and acute-phase proteins. IL1B is predominantly produced by activated monocytes, macrophages, and dendritic cells during infections, tissue damage, or inflammatory conditions. It plays a critical role in immune cell recruitment, pathogen clearance, and tissue repair, but excessive IL1B signaling leads to chronic inflammation, autoimmune disorders, and tumor progression. Dysregulation of IL1B is implicated in diseases such as rheumatoid arthritis, gout, and neuroinflammation. Knockout studies demonstrate impaired inflammatory responses, reduced cytokine production, and weakened host defense, highlighting IL1B's essential role in immune activation, inflammation, and disease pathogenesis.
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