Integrin Alpha M / CD11b (ITGAM) Antibody (Biotin)
507€ (0.5 mg)
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935106861
info@markelab.com
name
Integrin Alpha M / CD11b (ITGAM) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx137128
Description
Integrin Alpha M / CD11b (ITGAM) Antibody is a Mouse Monoclonal antibody against Integrin Alpha M / CD11b (ITGAM).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Alpha M / CD11b (ITGAM) |
| Host | Mouse |
| Reactivity | Human |
| Assay Data | Modification: Biotinylated |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Biotin |
| Size 1 | 0.5 mg |
| Size 2 | 1 mg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | CR3A,MO1A,CD11B,MAC-1,MAC1A,SLEB6,CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor |
| Background | Antibody anti-ITGAM |
| Status | RUO |
Descripción
Integrin Subunit Alpha M (ITGAM), also known as CD11b, is a transmembrane glycoprotein expressed predominantly on the surface of monocytes, macrophages, granulocytes, and some dendritic cells. ITGAM forms a heterodimer with integrin beta-2 (ITGB2) to create the Mac-1 complex, which is crucial in mediating adhesion and migration of leukocytes during inflammatory and immune responses. The protein plays a pivotal role in immune surveillance and host defense by facilitating phagocytosis, complement receptor activity, and migration across endothelial barriers. Additionally, ITGAM is involved in the recognition and clearance of pathogens and apoptotic cells. Aberrations in ITGAM expression or mutations have been linked to systemic lupus erythematosus (SLE) and other autoimmune disorders. It is also a key player in immune evasion mechanisms employed by certain pathogens.
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