Integrin Alpha M / CD11b (ITGAM) Antibody
221€ (0.1 mg)
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Name
Integrin Alpha M / CD11b (ITGAM) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139619
Tested Applications
IHC, FCM, IP, FUNC
Description
Integrin alpha M (ITGAM) Antibody is a Rat Monoclonal against Integrin alpha M (ITGAM).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin Alpha M / CD11b (ITGAM) Immunogen: B10 mouse spleen cells enriched for T cells. |
| Host | Rat |
| Reactivity | Human, Mouse, Rabbit, Monkey |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Clone ID | Y867 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein G affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM, IP, FUNC |
| Buffer | LE/AF PBS solution, 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | G5E8F1 |
| Gene ID | 16409 |
| Alias | CR3A,MO1A,CD11B,MAC-1,MAC1A,SLEB6,CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor |
| Background | Antibody anti-ITGAM |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Integrin Subunit Alpha M (ITGAM), also known as CD11b, is a transmembrane glycoprotein expressed predominantly on the surface of monocytes, macrophages, granulocytes, and some dendritic cells. ITGAM forms a heterodimer with integrin beta-2 (ITGB2) to create the Mac-1 complex, which is crucial in mediating adhesion and migration of leukocytes during inflammatory and immune responses. The protein plays a pivotal role in immune surveillance and host defense by facilitating phagocytosis, complement receptor activity, and migration across endothelial barriers. Additionally, ITGAM is involved in the recognition and clearance of pathogens and apoptotic cells. Aberrations in ITGAM expression or mutations have been linked to systemic lupus erythematosus (SLE) and other autoimmune disorders. It is also a key player in immune evasion mechanisms employed by certain pathogens.
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