Insulin Receptor (INSR) Antibody
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Description
Insulin Receptor (INSR) Antibody is a Mouse Monoclonal antibody for the detection of Insulin Receptor (INSR) in Human samples.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Insulin Receptor (INSR) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a Kappa |
| Clone ID | E383 |
| Purity | > 95% |
| Purification | Purified by Protein A/G affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06213 |
| Gene ID | 3643 |
| NCBI Accession | NP_000199.2 |
| Alias | HHF5,CD220,IR |
| Background | Antibody anti-INSR |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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INSR antibody
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
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