INSR (pY1150) / IGF1R (pY1135) Antibody
208€ (20 µl)
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name
INSR (pY1150) / IGF1R (pY1135) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx000129
tested applications
ELISA, WB
Description
INSR (pY1150) / IGF1R (pY1135) Antibody is a Rabbit Polyclonal antibody against INSR (pY1150) / IGF1R (pY1135). Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | INSR (pY1150) / IGF1R (pY1135) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: INSR: Tyr1150 IGF1R: Tyr1135 |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06213, P08069 |
| Gene ID | 3643 |
| NCBI Accession | NP_001073285.1 |
| Alias | HHF5,CD220,IR |
| Background | Antibody anti-INSR |
| Status | RUO |
| Note | Concentration: 2.42 mg/ml - |
Descripción
The insulin receptor (INSR) is a transmembrane protein essential for regulating glucose homeostasis, cellular growth, and metabolism. This receptor, which belongs to the receptor tyrosine kinase (RTK) family, is the primary signaling molecule for insulin, a hormone central to controlling blood sugar levels. By binding insulin, the INSR initiates a cascade of signaling pathways that drive glucose uptake, protein synthesis, lipid metabolism, and cell proliferation. Dysregulation of INSR signaling is implicated in various metabolic and endocrine diseases, most notably type 2 diabetes mellitus (T2DM), obesity, and insulin resistance-related disorders. The receptor’s role in modulating these critical physiological processes makes it a focus for therapeutic interventions and research in metabolic diseases.
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This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
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