Insulin Receptor (INSR) Antibody
312€ (60 µl)
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Name
Insulin Receptor (INSR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx000670
Tested Applications
WB, IP
Description
INSR Antibody is a Rabbit Polyclonal antibody against INSR. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Insulin Receptor (INSR) Immunogen: Recombinant fusion protein corresponding to human INSR |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IP: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 155 kDa/156 kDa Observed MW: 110 kDa/220 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IP |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06213 |
| Gene ID | 3643 |
| NCBI Accession | NP_000199.2 |
| OMIM | 125853 |
| Alias | HHF5,CD220,IR |
| Background | Antibody anti-INSR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The insulin receptor (INSR) is a transmembrane protein essential for regulating glucose homeostasis, cellular growth, and metabolism. This receptor, which belongs to the receptor tyrosine kinase (RTK) family, is the primary signaling molecule for insulin, a hormone central to controlling blood sugar levels. By binding insulin, the INSR initiates a cascade of signaling pathways that drive glucose uptake, protein synthesis, lipid metabolism, and cell proliferation. Dysregulation of INSR signaling is implicated in various metabolic and endocrine diseases, most notably type 2 diabetes mellitus (T2DM), obesity, and insulin resistance-related disorders. The receptor’s role in modulating these critical physiological processes makes it a focus for therapeutic interventions and research in metabolic diseases.
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