Insulin-like Growth Factor Binding Protein 2 (IGFBP-2) ELISA
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Description
Measurement of human IGFBP-2 concentration (insulin-like growth factor binding protein 2) in human serum, EDTA-plasma. Elevated IGFBP-2 concentrations represent a possible marker for tumor diseases such as liver carcinomas, prostate cancer and brain tumors.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Assay Data | Reference Material: recombinant IGFBP-2 Incubation Period: 1.75h Calibrator: human IGFBP-2 Controls: lyophilised ( 2 controls) |
| Assay Type | Sandwich |
| Test Range | 0.2 – 1680 µg/L |
| Sensitivity | 0.2 µg/L |
| Recommended Dilution | 1:21 |
| Origin | Antibody: Rabbit |
| Size 1 | 96 det. |
| Tested Applications | Elisa |
| Sample Type | Serum EDTA / Heparin Plasma |
| Availability | 3-5 days. |
| Storage | Shelf life: between 1 and 2 years Store the kit at 2-8°C after receipt until its expiry date. |
| Alias | IBP2, IGF-BP53 |
| Background | Elisa Kits for: IGFBP2 |
| Status | IVD |
| Note | Intra/Interassay Variance [%]< 10 |
Descripción
Medición de la concentración de IGFBP-2 (proteína transportadora del factor de crecimiento insulínico tipo 2) en suero humano y plasma con EDTA. Las concentraciones elevadas de IGFBP-2 representan un posible marcador de enfermedades tumorales como carcinomas hepáticos, cáncer de próstata y tumores cerebrales.
Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of growth hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of fetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGF-forms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism.
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