Human Acid Labile Subunit (ALS) ELISA
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
This enzyme immunoassay kit is suited for measuring ALS in human serum or EDTA/heparin/citrate plasma for scientific purposes.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Assay Data | Reference Material: recombinant ALS Incubation Period: 3h Calibrator: native human ALS Controls: 2 control sera, freeze-dried |
| Assay Type | Sandwich |
| Test Range | 0.53 - 30 000 [ng/mL] |
| Sensitivity | 0.53 ng/mL |
| Recommended Dilution | 1:150 |
| Origin | Antibody: Rabbit |
| Size 1 | 96 det. |
| Tested Applications | Elisa |
| Sample Type | Serum EDTA / Heparin Plasma |
| Availability | 3-5 days. |
| Storage | Shelf life: between 1 and 2 years Store the kit at 2-8°C after receipt until its expiry date |
| Alias | ALS, ACLSD, insulin like growth factor binding protein acid labile subunit |
| Background | Elisa Kits for: IGFALS |
| Status | RUO |
| Note | Intra/Interassay Variance [%]<10 |
Descripción
Kit de inmunoensayo enzimático adecuado para medir ALS en suero humano o plasma con EDTA/heparina/citrato con fines científicos.
The Insulin-like Growth Factors (IGF) – I and II are bound to specific binding proteins in circulation (IGFBP). Until today seven different proteins have been identified: IGFBP-1 to 7. IGF bioavailability, transport and storage is regulated and facilitated by these binding proteins which are expressed differentially according physiological and developmental requirements. The most abundant IGFBP in circulation is IGFBP-3. Together with IGFBP-5 it is able to form the so called ternary complex with IGF and the acid-labile subunit (ALS). In the circulation nearly all IGF is bound in this ternary complex and thus not able to cross the endothelial barrier. Only very small amounts of IGF or IGFBP-3 exist outside this complex. The acid-labile subunit is an important part of the IGF-storage mechanism in circulation. In ALS deficiency or in ALS knock-out mice the concentrations of IGF and IGFBP-3 in the circulation are significantly decreased thus resulting in impaired growth.
Related Products
Human Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) ELISA
This enzyme immunoassay kit is suited for measuring IGFBP-3 in human serum, EDTA and Heparin-plasma for diagnostic and scientific purposes. Serum IGFBP-3 concentration is influenced by growth hormone, age, sexual development stage, diet, hypothyroidism, diabetes mellitus, liver and kidney functions. In clinical diagnostics, serum IGFBP-3 concentration can be used to diagnose growth hormone deficiency and excess.
Ver ProductoHuman Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) LIA
This Ligand-binding Immunoassay kit is suited for measuring human bioactive and functional - IGF-I binding - IGFBP-3. In conjunction with correspondent measurements in the same samples of total IGFBP-3 (tIGFBP-3) with respective Mediagnost kits E03, IGF-R10, or, IGF-R11, the degree of fragmentated IGFBP-3 can be determined
Ver ProductoInsulin-like Growth Factor Binding Protein 2 (IGFBP-2) ELISA
Measurement of human IGFBP-2 concentration (insulin-like growth factor binding protein 2) in human serum, EDTA-plasma. Elevated IGFBP-2 concentrations represent a possible marker for tumor diseases such as liver carcinomas, prostate cancer and brain tumors.
Ver Producto