Human Acid Labile Subunit (ALS) ELISA
536€ (96 det.)
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Name
Human Acid Labile Subunit (ALS) ELISA
Category
ELISA Kits
Provider
Mediagnost
Reference
E35
Tested Applications
Elisa
Description
This enzyme immunoassay kit is suited for measuring ALS in human serum or EDTA/heparin/citrate plasma for scientific purposes.
Descripción
Kit de inmunoensayo enzimático adecuado para medir ALS en suero humano o plasma con EDTA/heparina/citrato con fines científicos.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Assay Data | Reference Material: recombinant ALS Incubation Period: 3h Calibrator: native human ALS Controls: 2 control sera, freeze-dried |
| Assay Type | Sandwich |
| Test Range | 0.53 - 30 000 [ng/mL] |
| Sensitivity | 0.53 ng/mL |
| Recommended Dilution | 1:150 |
| Origin | Antibody: Rabbit |
| Size 1 | 96 det. |
| Tested Applications | Elisa |
| Sample Type | Serum EDTA / Heparin Plasma |
| Availability | 3-5 days. |
| Storage | Shelf life: between 1 and 2 years. Inquire about availability Store the kit at 2-8°C after receipt until its expiry date |
| Alias | ALS, ACLSD, insulin like growth factor binding protein acid labile subunit |
| Background | Elisa Kits for: IGFALS |
| Status | RUO |
| Note | Intra/Interassay Variance [%]<10 |
Background
The Insulin-like Growth Factors (IGF) – I and II are bound to specific binding proteins in circulation (IGFBP). Until today seven different proteins have been identified: IGFBP-1 to 7. IGF bioavailability, transport and storage is regulated and facilitated by these binding proteins which are expressed differentially according physiological and developmental requirements. The most abundant IGFBP in circulation is IGFBP-3. Together with IGFBP-5 it is able to form the so called ternary complex with IGF and the acid-labile subunit (ALS). In the circulation nearly all IGF is bound in this ternary complex and thus not able to cross the endothelial barrier. Only very small amounts of IGF or IGFBP-3 exist outside this complex. The acid-labile subunit is an important part of the IGF-storage mechanism in circulation. In ALS deficiency or in ALS knock-out mice the concentrations of IGF and IGFBP-3 in the circulation are significantly decreased thus resulting in impaired growth.
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