Immunoglobulin Superfamily Member 8 (IGSF8) Antibody
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935106861
info@markelab.com
Precio
281.25€ (80 µl)
Antibody anti-IGSF8
proveedor
Abbexareference
abx026774Tested Applications
ELISA, WB, IHCreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
IGSF8 may play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Background
IGSF8, also known as ECD8 or CD316, is expressed in a wide range of tissues, including immune cells, neuronal cells, and epithelial cells. It contains Ig-like domains and functions as a co-receptor involved in cell adhesion, cell signaling, and immune modulation. IGSF8 interacts with integrins and tetraspanins, playing a role in immune cell activation, antigen presentation, and synaptic organization. In the immune system, it facilitates interactions between antigen-presenting cells and T cells. Dysregulation of IGSF8 is linked to neurodegenerative diseases, such as Alzheimer’s disease, and its altered expression is observed in certain cancers, where it influences tumor-immune interactions and metastasis.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Immunoglobulin Superfamily Member 8 (IGSF8)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified through a protein A column, followed by peptide affinity purification.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
IGSF8
dry ice
No
availability
Shipped within 5-10 working days.
alias
EWI2,PGRL,CD316,EWI-2,KCT-4,CD81P3,LIR-D1,Prostaglandin regulatory-like protein,CD81 partner 3,Glu-Trp-Ile EWI motif-containing protein 2
uniprot id
note
This product is for research use only.
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