DNA-Binding Protein Ikaros (IKZF1) Antibody
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Description
DNA-binding protein Ikaros (IKZF1) Antibody is a Goat Polyclonal antibody against DNA-binding protein Ikaros (IKZF1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DNA-Binding Protein Ikaros (IKZF1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 10320, 22778 |
| NCBI Accession | NP_006051.1, NP_001207694.1, NP_001207695.1, NP_001207696.1, NP_001207697.1, NP_001207698.1, NP_001207699.1, NP_001207700.1 and more |
| Background | Antibody anti-IKZF1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
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Human IKZF1 (DNA-binding protein Ikaros) ELISA Kit
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IKZF1 antibody
Transcription regulator of hematopoietic cell differentiation(PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer(delta-A element) of the CD3-delta gene. Repressor of the TDT(fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF(SWI/SNF), in a single complex(PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells(RPCs)(By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms(PubMed:17135265, PubMed:17934067).
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