IKZF1 antibody
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Description
Transcription regulator of hematopoietic cell differentiation(PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer(delta-A element) of the CD3-delta gene. Repressor of the TDT(fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF(SWI/SNF), in a single complex(PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells(RPCs)(By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms(PubMed:17135265, PubMed:17934067).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | IKAROS family zinc finger 1(Ikaros) (IKZF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 53 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13422 |
| Gene ID | 10320 |
| Alias | DNA-binding protein Ikaros,Ikaros family zinc finger protein 1,Lymphoid transcription factor LyF-1,IKZF1,IK1,IKAROS,LYF1,ZNFN1A1 |
| Background | Antibody anti-IKZF1 |
| Status | RUO |
| Note | Mol. Weight 57-70 kDa |
Descripción
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IKZF1 antibody
Transcription regulator of hematopoietic cell differentiation(PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer(delta-A element) of the CD3-delta gene. Repressor of the TDT(fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF(SWI/SNF), in a single complex(PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells(RPCs)(By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms(PubMed:17135265, PubMed:17934067).
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