Human Zinc finger MIZ domain-containing protein 2 (ZMIZ2) ELISA Kit

Product specifications

ELISA Kits

Zinc finger MIZ domain-containing protein 2 (ZMIZ2)

Human

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q8NF64

611196

NET27,TRAFIP20,ZIMP7,Hzimp7,


PIAS-like protein Zimp7

Elisa kits for ZMIZ2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Zinc Finger MIZ-Type Containing 2 (ZMIZ2) is a transcriptional co-activator of the PIAS-like family, containing a MIZ domain that mediates interactions with transcription factors and chromatin regulators It enhances the transcriptional activity of androgen receptors (AR) and interacts with pathways such as p53, SMAD, and Wnt signaling ZMIZ2 contributes to essential cellular processes including proliferation, differentiation, DNA repair, and hematopoietic stem cell regulation Its role in immune cell function and T-cell activation highlights its importance in immune homeostasis Dysregulation of ZMIZ2 expression or mutations has been linked to cancers including prostate, breast, and colorectal cancers, where it can promote oncogenic transcriptional activity and enhance tumor progression ZMIZ2 has also been implicated in autoimmune diseases such as lupus and multiple sclerosis due to its involvement in immune tolerance and inflammatory responses Emerging studies suggest its function in modulating chromatin accessibility and epigenetic regulation, making it a key player in transcriptional regulation and cellular homeostasis

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