Human UBX domain-containing protein 4 (UBXN4) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human UBX domain-containing protein 4 (UBXN4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx552430
tested applications
ELISA
Description
Human UBX domain-containing protein 4 (UBXN4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human UBX domain-containing protein 4 (UBXN4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | UBX domain-containing protein 4 (UBXN4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q92575 |
| OMIM | 611216 |
| Alias | UBXD2,UBXDC1,erasin |
| Background | Elisa kits for UBXN4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
UBX domain protein 4 (UBXN4) is a member of the UBX domain-containing protein family that interacts with p97/VCP, a critical ATPase in protein quality control pathways UBXN4 functions as a cofactor that regulates p97 activity during endoplasmic reticulum-associated degradation (ERAD) and the ubiquitin-proteasome system It facilitates the extraction of misfolded proteins from the ER membrane for degradation, maintaining cellular proteostasis under stress conditions UBXN4 is also involved in autophagy and cellular stress responses by coordinating p97-dependent protein turnover Emerging evidence links UBXN4 to DNA damage repair pathways, where it regulates protein stability at replication forks Dysregulation of UBXN4 is associated with neurodegenerative disorders, such as Alzheimer’s disease, where impaired protein clearance results in toxic aggregates Studies also highlight its role in cancer progression, where UBXN4 supports proteasome-mediated protein turnover, contributing to tumor survival and therapy resistance Its ability to regulate proteostasis and stress responses underscores its importance in cellular quality control
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