Human Tyrosine 3/Tryptophan 5 Monooxygenase Activation Protein Theta (YWHAq) Protein
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Description
Human YWHAq Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tyrosine 3/Tryptophan 5 Monooxygenase Activation Protein Theta (YWHAq) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 31.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Glu241 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P27348 |
| Alias | YWHAQ, 14-3-3, 1C5, HS1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
| Background | Protein YWHAQ |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
YWHAQ, also known as 14-3-3 theta, functions as a scaffold protein that regulates signal transduction, apoptosis, and cell cycle progression by binding phosphorylated proteins. It interacts with signaling molecules involved in pathways such as MAPK, PI3K/Akt, and TGF-β, facilitating processes like cellular growth, survival, and differentiation. YWHAQ is abundantly expressed in neuronal tissues and skeletal muscle, where it plays a role in synaptic function, axonal transport, and cellular energy metabolism. It regulates neuroprotective pathways by stabilizing proteins involved in neuronal survival and oxidative stress responses. Dysregulation of YWHAQ is linked to neurodegenerative diseases such as Parkinson’s and Huntington’s, where its dysfunction leads to impaired signaling and protein aggregation. In cancer, overexpression of YWHAQ promotes cell proliferation and migration through its effects on oncogenic signaling pathways. Knockout studies demonstrate defects in cell survival, impaired neuronal development, and altered metabolic responses, highlighting its role in neuroprotection, cellular stability, and disease regulation.
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14-3-3 theta(also known as YWHAQ, or 14-3-3 tau) is a member of 14-3-3 proteins which were the first phosphoserine/phosphothreonine-binding proteins to be discovered. 14-3-3 family members interact with a wide spectrum of proteins and possess diverse functions. Mammals express seven distinct 14-3-3 isoforms(gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo-and hetero-dimmers. 14-3-3 proteins display the highest expression levels in the brain, and have been implicated in several neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This antibody was raised against full-length 14-3-3 theta.
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14-3-3 theta(also known as YWHAQ, or 14-3-3 tau) is a member of 14-3-3 proteins which were the first phosphoserine/phosphothreonine-binding proteins to be discovered. 14-3-3 family members interact with a wide spectrum of proteins and possess diverse functions. Mammals express seven distinct 14-3-3 isoforms(gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo-and hetero-dimmers. 14-3-3 proteins display the highest expression levels in the brain, and have been implicated in several neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This antibody was raised against full-length 14-3-3 theta.
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