14-3-3 Protein Theta (YWHAQ) Antibody
195€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
14-3-3 Protein Theta (YWHAQ) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx002000
Tested Applications
ELISA, WB
Description
YWHAQ Antibody is a Rabbit Polyclonal antibody against YWHAQ. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 14-3-3 Protein Theta (YWHAQ) Immunogen: Synthetic peptide corresponding to YWHAQ. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 28 kDa Observed MW: 32 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P27348 |
| Gene ID | 10971 |
| NCBI Accession | NP_006817.1 |
| Alias | YWHAQ, 14-3-3, 1C5, HS1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
| Background | Antibody anti-YWHAQ |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
YWHAQ, also known as 14-3-3 theta, functions as a scaffold protein that regulates signal transduction, apoptosis, and cell cycle progression by binding phosphorylated proteins. It interacts with signaling molecules involved in pathways such as MAPK, PI3K/Akt, and TGF-β, facilitating processes like cellular growth, survival, and differentiation. YWHAQ is abundantly expressed in neuronal tissues and skeletal muscle, where it plays a role in synaptic function, axonal transport, and cellular energy metabolism. It regulates neuroprotective pathways by stabilizing proteins involved in neuronal survival and oxidative stress responses. Dysregulation of YWHAQ is linked to neurodegenerative diseases such as Parkinson’s and Huntington’s, where its dysfunction leads to impaired signaling and protein aggregation. In cancer, overexpression of YWHAQ promotes cell proliferation and migration through its effects on oncogenic signaling pathways. Knockout studies demonstrate defects in cell survival, impaired neuronal development, and altered metabolic responses, highlighting its role in neuroprotection, cellular stability, and disease regulation.
Productos relacionados
14-3-3 Protein Theta (YWHAQ) Antibody
YWHAQ Antibody is a Rabbit Polyclonal antibody against YWHAQ. This gene product belongs to the 14-3-3 family of proteins…
Ver producto
14-3-3 Protein Theta (YWHAQ) Antibody
Rabbit polyclonal antibody against 14-3-3 theta protein. Immunogen region is Internal.…
Ver producto
Human 14-3-3 Protein Theta (YWHAQ) Protein
Tyr-3/trp-5 Monooxygenase Activation Protein, Tau Protein is a recombinant protein kinase.…
Ver producto