Human Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B) Protein

Este producto es parte de TNFRSF13B - TNF receptor superfamily member 13B
Human Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B) Protein
624€ (50 µg)

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Name
Human Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx655850
Tested Applications
WB, SDS-PAGE

Description

Human Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) Protein (Active) is an Active recombinant Human protein.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B)
Assay Type
Activity: Active
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 90%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
Tumor necrosis factor receptor superfamily member 13B,CVID,RYZN,TACI,CD267,CVID2,IGAD2,TNFRSF14B,Transmembrane activator and CAML interactor
Background
Protein TNFRSF13B
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

TNFRSF13B, also known as TACI (Transmembrane Activator and CAML Interactor), is a critical receptor in the immune system, specifically involved in B cell biology. TNFRSF13B belongs to the tumor necrosis factor receptor superfamily (TNFRSF) and plays an essential role in immune regulation by binding ligands such as APRIL (a proliferation-inducing ligand) and BAFF (B-cell activating factor). These interactions are vital for B cell survival, proliferation, and differentiation, particularly in the context of generating long-lasting immune responses and maintaining immune homeostasis. Mutations in TNFRSF13B have been linked to various immunodeficiency disorders, such as Common Variable Immunodeficiency (CVID) and IgA deficiency. These conditions are associated with impaired antibody production, resulting in increased susceptibility to infections and autoimmune complications. Due to its importance in regulating immune responses, TNFRSF13B is studied intensively as a therapeutic target for both immunodeficiency disorders and autoimmune diseases where B cell activity is dysregulated.

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