Human Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B) Protein (Active)
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935106861
info@markelab.com
Precio
3612.5€ (1 mg)
Protein TNFRSF13B
proveedor
Abbexareference
abx655850Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) Protein (Active) is an Active Recombinant Human protein.
Background
TNFRSF13B, also known as TACI (Transmembrane Activator and CAML Interactor), is a critical receptor in the immune system, specifically involved in B cell biology. TNFRSF13B belongs to the tumor necrosis factor receptor superfamily (TNFRSF) and plays an essential role in immune regulation by binding ligands such as APRIL (a proliferation-inducing ligand) and BAFF (B-cell activating factor). These interactions are vital for B cell survival, proliferation, and differentiation, particularly in the context of generating long-lasting immune responses and maintaining immune homeostasis. Mutations in TNFRSF13B have been linked to various immunodeficiency disorders, such as Common Variable Immunodeficiency (CVID) and IgA deficiency. These conditions are associated with impaired antibody production, resulting in increased susceptibility to infections and autoimmune complications. Due to its importance in regulating immune responses, TNFRSF13B is studied intensively as a therapeutic target for both immunodeficiency disorders and autoimmune diseases where B cell activity is dysregulated.
Características del producto
category
Proteins and Peptides
origin
Human
immunogen target
Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B)
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TNFRSF13B
dry ice
No
availability
Shipped within 1-2 months.
alias
Tumor necrosis factor receptor superfamily member 13B,CVID,RYZN,TACI,CD267,CVID2,IGAD2,TNFRSF14B,Transmembrane activator and CAML interactor
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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