Human Transmembrane Emp24 Domain-Containing Protein 7 (TMED7) ELISA Kit
715€ (96 tests)
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name
Human Transmembrane Emp24 Domain-Containing Protein 7 (TMED7) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx550425
tested applications
ELISA
Description
Human Transmembrane emp24 domain-containing protein 7 ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Transmembrane emp24 domain-containing protein 7 concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transmembrane Emp24 Domain-Containing Protein 7 (TMED7) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9Y3B3 |
| Gene ID | 51014 |
| Alias | CGI-109, Tag, p24g3, p24gamma3, p27,p24 family protein gamma-3,p24gamma3 |
| Background | Elisa Kits for: TMED7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
TMED7, a key p24 family protein, regulates the trafficking of proteins and receptors through the early secretory pathway, connecting the ER, ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. It functions as a cargo receptor, enabling the export of correctly folded proteins in COPII-coated vesicles and mediating their retrieval via COPI. TMED7 also influences receptor signaling and immune responses, particularly through its involvement in toll-like receptor (TLR) pathways, where it modulates TLR4 trafficking and downstream activation of pro-inflammatory signaling cascades. TMED7 is widely expressed across immune cells and secretory tissues, where it supports vesicular transport efficiency, receptor localization, and cytokine production. Dysregulation of TMED7 is implicated in immune disorders, neurodegeneration, and cancers, where disrupted protein trafficking and receptor signaling contribute to disease pathogenesis. Knockdown studies reveal reduced TLR signaling, impaired vesicle formation, and increased ER stress, underscoring its role in vesicle trafficking, immune signaling, and cellular homeostasis.
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