Human Transcription Factor AP-2 Beta (TFAP2B) ELISA Kit

Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for TFAP2B
proveedor
Abbexareference
abx253889Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Transcription Factor AP-2 Beta (TFAP2B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Transcription factor AP-2-beta concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TFAP2B, a member of the AP-2 transcription factor family, regulates gene expression by binding to GC-rich DNA sequences in promoter regions. It plays a key role in embryonic development, particularly in neural crest formation, cardiovascular system development, and kidney morphogenesis. TFAP2B contributes to cell proliferation, differentiation, and survival by controlling the transcription of genes involved in apoptosis, cell adhesion, and growth. Mutations in TFAP2B are associated with autosomal dominant Char syndrome, a congenital disorder characterized by heart defects, limb anomalies, and facial dysmorphisms. TFAP2B also plays a role in tumorigenesis, where its altered expression influences cell cycle progression, epithelial-mesenchymal transition (EMT), and metastasis in cancers such as breast and neuroblastoma. Knockout studies show developmental defects in cardiovascular structures and impaired neural crest cell migration, highlighting TFAP2B's essential role in organ development, tissue differentiation, and cell fate determination.
Características del producto
category
ELISA Kits
immunogen target
Transcription Factor AP-2 Beta (TFAP2B)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.1 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
AP-2B,AP-2beta,AP2-B,PDA2,Activating enhancer-binding protein 2-beta
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TFAP2B
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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