Human Transcription Factor AP-2 Beta (TFAP2B) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Transcription Factor AP-2 Beta (TFAP2B) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx253889
tested applications
ELISA
Description
Human Transcription Factor AP-2 Beta (TFAP2B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Transcription factor AP-2-beta concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transcription Factor AP-2 Beta (TFAP2B) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.1 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q92481 |
| Alias | AP-2B,AP-2beta,AP2-B,PDA2,Activating enhancer-binding protein 2-beta |
| Background | Elisa kits for TFAP2B |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TFAP2B, a member of the AP-2 transcription factor family, regulates gene expression by binding to GC-rich DNA sequences in promoter regions. It plays a key role in embryonic development, particularly in neural crest formation, cardiovascular system development, and kidney morphogenesis. TFAP2B contributes to cell proliferation, differentiation, and survival by controlling the transcription of genes involved in apoptosis, cell adhesion, and growth. Mutations in TFAP2B are associated with autosomal dominant Char syndrome, a congenital disorder characterized by heart defects, limb anomalies, and facial dysmorphisms. TFAP2B also plays a role in tumorigenesis, where its altered expression influences cell cycle progression, epithelial-mesenchymal transition (EMT), and metastasis in cancers such as breast and neuroblastoma. Knockout studies show developmental defects in cardiovascular structures and impaired neural crest cell migration, highlighting TFAP2B's essential role in organ development, tissue differentiation, and cell fate determination.
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Human TFAP2B (Transcription factor AP-2-beta) ELISA Kit
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TFAP2B antibody
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
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