Human Toll Like Receptor 9 (TLR9) Protein
221€ (10 µg)
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935106861
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name
Human Toll Like Receptor 9 (TLR9) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166661
tested applications
WB, SDS-PAGE
Description
Toll Like Receptor 9 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Toll Like Receptor 9 (TLR9) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 41.1 kDa Observed MW (SDS-PAGE): 41 kDa Concentration: Prior to lyophilization: 500 µg/ml Sequence Fragment: Thr28-Ser362 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 80% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstiture in ddH2O. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NR96 |
| Alias | Toll-like receptor 9,CD289 |
| Background | Protein TLR9 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Toll-like receptor 9 (TLR9) is an integral component of the immune system and a member of the Toll-like receptor (TLR) family, primarily involved in the recognition of pathogen-associated molecular patterns (PAMPs) within microbial DNA. TLR9 is uniquely specialized to detect unmethylated CpG motifs in DNA, which are frequently found in bacterial and viral genomes but rare in vertebrate DNA due to methylation. This distinction allows TLR9 to effectively recognize pathogenic DNA and initiate immune responses against infections. By detecting microbial DNA, TLR9 plays a pivotal role in the innate immune response and contributes to the activation of adaptive immunity. TLR9 is expressed in plasmacytoid dendritic cells (pDCs), B cells, and monocytes/macrophages, with its expression localized to the endosomes of these cells. This intracellular positioning is essential for its function, as it enables the receptor to sample nucleic acids from pathogens engulfed in endosomal compartments. Upon recognizing CpG motifs, TLR9 initiates a signaling cascade that promotes cytokine production and type I interferon release, critical for mounting an immune defense against pathogens and influencing the maturation of dendritic cells and the activation of T and B cells.
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