Human Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
416€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694145
tested applications
SDS-PAGE
Description
Human Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 25.74 kDa Observed MW (SDS-PAGE): 75 kDa Sequence Fragment: Met1-Phe235 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | P48307 |
| Gene ID | 798 |
| OMIM | 633 |
| Alias | PP5,REF1,TFPI-2,Placental protein 5 |
| Background | Protein TFPI2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Tissue Factor Pathway Inhibitor 2 (TFPI2), another Kunitz-type inhibitor, is structurally similar to TFPI but exhibits distinct functions, primarily inhibiting plasmin and matrix metalloproteinases (MMPs). TFPI2 plays a critical role in modulating extracellular matrix degradation, cell migration, and angiogenesis, influencing processes like wound healing, tissue remodeling, and tumor progression. Unlike TFPI, TFPI2 is broadly expressed in various tissues and is frequently downregulated in cancers, where its loss contributes to tumor invasion, metastasis, and angiogenesis. Its epigenetic silencing through promoter hypermethylation is a hallmark in several malignancies, highlighting its potential as a tumor suppressor and biomarker for cancer diagnosis and prognosis.
Related Products
Human TFPI2 (Tissue factor pathway inhibitor 2) ELISA Kit
Ver Producto
Mouse TFPI2 (Tissue Factor Pathway Inhibitor 2) ELISA Kit
Ver Producto