Human Telomeric Repeat-Binding Factor 1 (TERF1) Protein
221€ (10 µg)
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Name
Human Telomeric Repeat-Binding Factor 1 (TERF1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx069254
Tested Applications
WB, SDS-PAGE
Description
Human Telomeric Repeat-Binding Factor 1 (TERF1) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Telomeric Repeat-Binding Factor 1 (TERF1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ile148-Lys428 Tag: N-terminal His tag and GST tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 64.7 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54274 |
| Gene ID | 7013 |
| OMIM | 600951 |
| Alias | NIMA-interacting protein 2,PIN2,TRBF1,TRF,TRF1, t-TRF1, hTRF1-AS |
| Background | Protein TERF1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
TERF1, also known as TRF1, is a key component of the shelterin complex that binds to double-stranded telomeric DNA, playing an essential role in telomere maintenance and genomic stability. TERF1 regulates telomere length by inhibiting telomerase activity, preventing inappropriate elongation of telomeres, and facilitating their replication and capping. It recruits other shelterin components and telomere-associated proteins to protect chromosome ends from being recognized as double-strand breaks, thereby preventing DNA damage responses and chromosome fusion. TERF1 is highly expressed in proliferative tissues, including stem cells and cancer cells, where telomere maintenance is critical for cellular longevity. Dysregulation of TERF1 contributes to telomere dysfunction, genomic instability, and diseases such as cancer and premature aging syndromes. Functional studies demonstrate that TERF1 deletion results in telomere uncapping, DNA damage accumulation, and activation of cell cycle arrest or apoptosis, underscoring its pivotal role in telomere integrity, chromosome stability, and cellular homeostasis.
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