Human Telomeric Repeat-Binding Factor 1 (TERF1) CLIA Kit
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935106861
info@markelab.com
Precio
845€ (96 tests)
CLIA Kits TERF1
proveedor
Abbexareference
abx493902Tested Applications
CLIAreactivity
Humanstatus
RUOclonality
Descripción
Human Telomeric Repeat-Binding Factor 1 (TERF1) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Background
TERF1, also known as TRF1, is a key component of the shelterin complex that binds to double-stranded telomeric DNA, playing an essential role in telomere maintenance and genomic stability. TERF1 regulates telomere length by inhibiting telomerase activity, preventing inappropriate elongation of telomeres, and facilitating their replication and capping. It recruits other shelterin components and telomere-associated proteins to protect chromosome ends from being recognized as double-strand breaks, thereby preventing DNA damage responses and chromosome fusion. TERF1 is highly expressed in proliferative tissues, including stem cells and cancer cells, where telomere maintenance is critical for cellular longevity. Dysregulation of TERF1 contributes to telomere dysfunction, genomic instability, and diseases such as cancer and premature aging syndromes. Functional studies demonstrate that TERF1 deletion results in telomere uncapping, DNA damage accumulation, and activation of cell cycle arrest or apoptosis, underscoring its pivotal role in telomere integrity, chromosome stability, and cellular homeostasis.
Características del producto
category
CLIA Kits
immunogen target
Telomeric Repeat-Binding Factor 1 (TERF1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.055 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Chemiluminescent
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
NIMA-interacting protein 2,PIN2,TRBF1,TRF,TRF1, t-TRF1, hTRF1-AS
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TERF1
dry ice
No
uniprot id
note
The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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