Human Succinate Receptor 1 (SUCNR1) ELISA Kit

Este producto es parte de SUCNR1 - Succinate Receptor 1
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Succinate Receptor 1 (SUCNR1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385453
tested applications
ELISA

Description

Human Succinate Receptor 1 (SUCNR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SUCNR1 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
Succinate Receptor 1 (SUCNR1)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.15 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9BXA5
Gene ID
56670
OMIM
606381
Alias
SUCNR1,succinate receptor 1,GPR91,P2Y purinoceptor 1,SUCNR1,G protein-coupled receptor 91
Background
Elisa Kits for: SUCNR1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

SUCNR1, also known as the succinate receptor, is a G protein-coupled receptor that is activated by succinate, an intermediate in the citric acid cycle and a key molecule in cellular metabolism. It primarily couples to Gi proteins, triggering intracellular signaling pathways that regulate vascular tone, inflammation, and metabolic processes. SUCNR1 is expressed in various tissues, including the kidney, vasculature, and immune cells. In the kidney, it plays a role in regulating blood pressure by modulating the renin-angiotensin system. In the vasculature, SUCNR1 is involved in regulating smooth muscle contraction and endothelial cell function, contributing to blood pressure homeostasis. Dysregulation of SUCNR1 has been linked to conditions such as hypertension, ischemia, and inflammation. SUCNR1 is also implicated in cancer progression, particularly in the context of tumor hypoxia. Targeting SUCNR1 with selective agonists or antagonists offers potential therapeutic strategies for managing metabolic diseases, cardiovascular disorders, and inflammation.

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