Human Sphingosine 1-phosphate receptor 4 (S1PR4) ELISA Kit

Este producto es parte de S1PR - Sphingosine 1 Phosphate Receptor
Human Sphingosine 1-phosphate receptor 4 (S1PR4) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for S1PR4

proveedor

Abbexa

reference

abx253806

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Sphingosine 1-phosphate receptor 4 (S1PR4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sphingosine 1-phosphate receptor 4 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

S1PR4 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), primarily expressed in hematopoietic cells, including lymphocytes, dendritic cells, and natural killer (NK) cells. S1PR4 couples to Gi and G12/13 proteins, regulating pathways like PI3K/Akt and Rho/ROCK, which control cell migration, immune responses, and cytoskeletal reorganization. S1PR4 plays a critical role in immune cell trafficking, influencing lymphocyte egress from lymphoid tissues and modulating inflammatory responses. It is involved in regulating dendritic cell maturation and T-cell function, positioning it as a key player in adaptive immunity. Dysregulation of S1PR4 is associated with autoimmune diseases, inflammatory disorders, and hematological malignancies. In cancer, S1PR4 has been linked to tumor progression and immune evasion, particularly in leukemia and lymphoma. S1PR4 antagonists are being explored for therapeutic use in autoimmune diseases and cancers by modulating immune cell function and migration, highlighting its importance in immune regulation.

Características del producto

category

ELISA Kits


immunogen target

Sphingosine 1-phosphate receptor 4 (S1PR4)


reactivity

Human


test range

125 pg/ml - 8000 pg/ml


sensitivity

< 89 pg/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

S1PR4,EDG6,LPC1,S1P4,SLP4,endothelial differentiation G protein-coupled receptor 6


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

S1PR4


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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reactivity

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