Human Single Ig IL-1-related receptor (SIGIRR) ELISA Kit
773.5€ (96 tests)
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name
Human Single Ig IL-1-related receptor (SIGIRR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385410
tested applications
ELISA
Description
Human Single Ig IL-1-related receptor (SIGIRR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SIGIRR concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Single Ig IL-1-related receptor (SIGIRR) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6IA17 |
| Gene ID | 24058 |
| Alias | SIGIRR, TIR8, IL-1R8,SIGIRR, TIR8, IL-1R8 |
| Background | Elisa kits for SIGIRR |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SIGIRR, also known as IL1R8 or TIR8, is a member of the interleukin-1 receptor (IL-1R) family but functions as a negative regulator of Toll-like receptor (TLR) and IL-1R signaling pathways. SIGIRR contains a single immunoglobulin-like domain and a Toll/interleukin-1 receptor (TIR) domain, which mediate its inhibitory activity by preventing the recruitment of adaptor proteins like MyD88 and IRAK. It dampens the activation of downstream pathways, including NF-κB, MAPK, and AP-1, which are central to pro-inflammatory cytokine production. SIGIRR is highly expressed in epithelial cells, immune cells, and tissues like the intestine, lung, and kidney, where it helps maintain immune tolerance and protect against excessive inflammation. Dysregulation or deficiency of SIGIRR is linked to chronic inflammatory diseases, including inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), and autoimmune disorders, where unchecked signaling exacerbates tissue damage. Knockout studies reveal heightened inflammatory responses, increased cytokine production, and susceptibility to autoimmune and infectious diseases, emphasizing its role as a negative regulator in inflammation, immune homeostasis, and tissue protection.
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