Human Signaling Lymphocytic Activation Molecule Family Member 1 / CD150 (SLAMF1) Protein (Active)
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Description
Human CD150 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human SLAM (NP_003028.1) precursor (Met 1-Pro 258) with a C-terminal polyhistidine tag was expressed.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Signaling Lymphocytic Activation Molecule Family Member 1 / CD150 (SLAMF1) |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 25.8 kDa Sequence Fragment: Met1-Pro258 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_003028.1 |
| Alias | Signaling lymphocytic activation molecule,SLAM,CD150,CDw150,IPO-3,SLAM family member 1 |
| Background | Protein SLAMF1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SLAMF1, also known as CD150, is a membrane glycoprotein and member of the signaling lymphocytic activation molecule (SLAM) family, which plays a critical role in modulating immune responses. It is encoded by the SLAMF1 gene and is primarily expressed on the surface of several immune cells, such as T cells, B cells, macrophages, and dendritic cells. SLAMF1 functions as a self-ligand, allowing it to engage in homophilic interactions that are essential for intercellular communication in immune responses. It influences a variety of immune processes, including cell activation, proliferation, cytokine production, and cytotoxic functions. This molecule plays a significant role in adaptive immunity by regulating immune cell interactions, positioning it as a critical factor in the immune response to pathogens and in autoimmune conditions.
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CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signalinglymphocyte activation molecule) orIPO-3. CD150, asingle chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained onTh1 but notTh2 clones.Tregulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-g production byTh1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoieticstem cell studies.
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